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Keep track of Closely (3)pentobarbital will lower the level or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Potent or moderate CYP3A4 inducers might increase charge of diazepam elimination; therefore, efficacy of diazepam could be lowered.Barbiturates can induce hepatic microsoma